Authored By: B. V Waghmare

Wednesday, November 19, 2008

What is AIDS|HIV virus|information on HIV |Will there be a complete cure for AIDS |What is HAART |What is life span of a individual infected with HIV

Friends looking at the questions which are asked to me constantly through lots of emails which i am receiving from all the corners of globe, i am going to answer all questions listed below regarding HIV AIDS.
What is AIDS ? What is HIV virus ?
Will there be a complete cure for AIDS?
What is life span of a individual infected with HIV ?
Will a person survive through out his life if he is found HIV positive and starts treatment early without missing his drugs ?
What is HAART ?
Why we can not develop a vaccine for HIV AIDS?
What are the difficulties for developing HIV AIDS vaccine ?
What is current latest development of Drugs for AIDS HIV ?
What is current treatment for AIDS ?
AIDS symptoms SYMPTOMS OF HIV HIV symptoms
What is latest treatment for AIDS what is ongoing research on HIV virus and AIDS treatment?
I am trying to answer all of these questions together in this post in short.
What is an AIDS? :
AIDS is a disease condition caused by infection of HIV virus, here the HIV virus infects human body part whose primary role in our body is to protect our body from all sorts of infection cough cold, fever and every infecting thing.
But since this protective system is under attack by HIV virus this system fails to protect individual from incoming infections and also from opportunistic infections.
You can read over this blog to know what opportunistic infections are over my earlier posts. What happens after is declared he is having AIDS:
The person’s body is under attack from several microorganisms, yeasts, bacteria and fungi, which results in condition of multiple infections.
What is life threatening part of AIDS?:
If an individual gets Tuberculosis it is a condition which has caused lot of losses of life
Can we save a life of person if he is diagnosed early?
Yes! Yes! We can.
A serious part of this disease is the trauma of having this disease.
But if an individual takes medication properly he can leave a better life.
For what types of medication is required for an individual , it totally depends on that individual what are the drugs which are effective in lowering HIV virus counts are given by continuous monitoring of lowering of HIV viral load.
Will there be a complete cure for AIDS?
My dear friends if any one today is telling some one that he can cure AIDS ,Then he is a great genetics scientist or a medicinal chemist who constantly visualizes the Mode of Acton of antiAIDS drugs or he is a FAKE.
Why I mentioned great genetics scientist or a medicinal chemist is that we can get cure rather a complete life saving treatment through these sciences.
Today we have chemotherapeutic agents (Silently™ (Maraviroc) which can bring viral load almost to non detectable lavel, and once we achieve this we can assure that a patient can live his normal life ,but he has to continue medication without compromising any thing.
In coming few years we are going to have a complete life saving treatment for AIDS, till then hold on live your life write to me!
How do you feel!
Engage your self in constructive work than thinking on what will happen to you.
One can live a complete meaningful life if he decides ,so decide it “you will survive’ and you will definitely survive .
Refer my earlier post about Dr Gero Huetter’s bone marrow transplantM, there are lots of hopes from his finding.
Why we are not able to develop a vaccine for AIDS?
We will be getting few vaccines in coming years which will provide prophylaxis for patients who are recently detected or who are more porn to get this infection, amongst this there is Personalized vaccine for AIDS refer my earlier post on Dr. Jean-Pierre Routy who has developed personalized vaccine for HIV AIDS which I am finding a prominent and promising vaccine for AIDS so far.
Its bit difficult to develop vaccine against AIDS HIV as the virus keeps on changing his identity from one individual to other , just imagine a thief changing his face every day so what you will do for that .
We have solution for every thing
How anti AIDS drugs are developed?
This part of my writing you will never find over any place around the world.
You will find it here only As I am a person who has written how we can develop an Anti AIDS drug, an effective anti retroviral drug way back before Zudovudine was developed, and surprisingly the molecule about which I had written in my college days came out in few years to treat the disease, so I was on correct track.
Today also I am providing very important information over this place, with the intention of developing an effective anti AIDS drug as soon as possible.

Thymineribonucliotide How these anti AIDS drugs act : There is only one difference in RNA and DNA that is a base Thymidine DNA contains thymidine and RNA contains Uracil . Picking up this difference if we develop analogous molecule which will act competitively for reverse transcriptase of HIV virus .It will block synthesis of all proteins and enzymes and DNA and this will kill HIV virus. This is an enzyme dependant mode of action and has lots of draw backs but the entire benefits over weighs on draw backs .


(5' position on Ribose sugar is placed with Azo moiety (-N=N) in place of (-OH ) hydroxyl of Thymine ribonuclieotide in our body it competes for Thymine ribonuclieotide as it is structurally similar which bring all similarities of action due to ionic and hydrogen bonding .)

Same principle was used in developing Acyclovir an antiviral drug which is used for herpis infection. Acyclovir is a Guanocine antimetabolite Guanocine is a Base which is a building block for DNA of a common virus (not of HIV virus) the ribose sugar in guanosine nucleotide is modified and replaced with a straight chain of carbon with a ester in between just to mimic ribose .

These Aniti AIDS drugs are as follows
ZUDOVUDINE Zidovudine Azidothymidine
Portmanteau inhibitors
Researchers have designed molecules which dually inhibit both reverse transcriptase (RT) and integrase (IN). These drugs are a type of "portmanteau inhibitors".
Which other drug is best candidate for future development

Taxol (paclitaxel) is a drug that interacts with microtubule proteins in a manner that catalyzes their formation from tubulin and stabilizes the resulting structures
Taxol was shown to bind to DNA and RNA at G–C, A–T, or A–U bases and the .The taxol–polynucleotide complexation is associated with a partial helix stabilization
This is one of recent finding .

Cre recombinase
It is a Type I topoisomerase from P1 bacteriophage which catalyzes site-specific recombination of DNA between loxP sites. This is used in Genetic recombination techniques and is termed as “Cre-mediated recombination”
Currently it is studied for knoking down the HIV VIRUS DNA from an active to inactive form of DNA which is inserted in human T-lymphocytes .
Its purely genetic engineering and has great promising future for this research.

What is HAART?
Its is Antiretroviral drugs are medications for the treatment of infection with HIV.
When several such drugs, typically three or four, are taken in combination, the approach is known as Highly active antiretroviral therapy, or HAART.
Best drugs are combined together and administered to patients with continues monitoring of HIV viral load or count, and the drugs best fit are given , these drugs have proved very valuable in current treatment for AIDS ,
latest treatment for AIDS:
This include prophylatic preventive measures by giving BCG vaccine to infected individual as early as possibel before he shows any symptom of AIDS,
i will write in detail in my coming post for what could be the best treatment for AIDS.

Keep reading this blog to find all sorts of information on HIV virus and information on AIDS.
What is the latest treatment for AIDS HIV,
What is current research and development over HIV AIDS vaccine and Anti AIDS therapy treatment .Information on HIV virus AIDS.

Send this blog by email to your friends and dear ones to fight against HIV AIDS ,by doing so you are joining me in the fight Against HIV AIDS ,there is a link below every post as email this post you can use this for emailing this blog to your friends.

Question and Answers about HIV Testing -->

Signes and symptoms of AIDS and HIV infection-->

Basic Information about HIV and AIDS ==>


Last updated : 19-Nov-2008

Thursday, November 13, 2008

Latest treatment for AIDS done with bone marrow transplant latest treatment for AIDS|Reveiw article oninformation on HIV virus | information on AIDS.

Latest treatment for AIDS done with bone marrow transplant latest treatment for AIDS:Review
I came across a news about latest treatment for aids by a German doctor Dr Gero Huetter who has claimed to have "cured" HIV in a patient by giving him a bone marrow transplant.

First off all any disease be it a common cold can not be claimed as “Cured”
as a health care professional I want to educate every one who is reading me , that we treat ,diseases and the process of treatment brings relief from the disease and we cant claim as we cured, its scientifically incorrect.Even though I am with this noble doctor Dr Gero Huetter, his efforts to provide treatment to HIV AIDS patients is great ,as his treatment has provided lots of hopes to every one of us working on this disease,AIDS.

As I have mentioned in my earlier post about Gene therapy for HIV AIDS , he has given bone marrow transplant to a HIV positive AIDS patient , as he says there are some peoples around the world who’s T-lympocytic cells are resistant to HIV infection .
this could prove as a great breakthrough as if this is true we can preferably treat an individual infected with HIV AIDS with gene therapy rather than a bone marrow transplant so that the same gene which is responsible for the resistance for HIV infection can be incorporated in HIV infected individuals which will not allow HIV virus to enter in new lympocytic cells which will eventually protect body .

This can bring great relief and life to millions affected with this disease . This latest treatment for AIDS HIV is required to be studied and developed further .
Hence hats off for Dr Gero Huetter .i sincerely congratulate him as his finding is of great value today.

I Salute him, i feel if this is required to be tested world wide .
As I have always insisted for treatment for AIDS ,rather than for AIDS Vaccine development .
As treatment is easier ,as we can develop several drug molecules to inhibit HIV virus infection process steps these are allready used in latest treatments for AIDS HIV

Vaccine development is very challenging and it will take lot of time by the time we want to treat so many peoples affected with HIV AIDS.
Even I am sure that in coming time we will get
DNA vaccines for HIV AIDS
Protein part vaccines HIV AIDS
Personalised vaccine for HIV AIDS
there are maney latest drugs for treatment of HIV AIDS under clinical trials

Dr Gero Huetter

Dr Gero Huetter’s AIDS treatment news says:
A 42-year-old American who is living in Berlin, has shown no trace of HIV virus for nearly two years since Dr Gero Huetter, who is a haematologist, operated up on him - a standard treatment for leukaemia, from which the patient was also suffering.
The breakthrough finding gives us hope for cutting-edge gene therapies to tackle the disease that killed 2 million people worldwide last year and infected another 2.7 million.
Working on a hunch, Dr Huetter selected a bone marrow donor who had a genetic resistance to most strains of HIV in the hope that the transplanted marrow would produce HIV-resistant cells in his patient.
It appears to have worked, and yesterday 13-Nov-08 Dr Huetter declared his patient ''functionally cured''.
The patient has taken no anti-retroviral drugs, the standard treatment for AIDS, since the transplant.
( I will recommend for continuous antiretroviral drugs therapy …as of today only chemotherapy has proved that the virus load almost goes to such extent that it is not detected ) read in detail over this website .
"HIV has an Achilles heel,'' Dr Huetter told a press conference in Berlin.
That "Achilles" heel is a molecule that sits on the outside of a human cell and acts as a doorway to let HIV invade the body.
People with the genetic resistance have a mutation which blocks the production of the molecule, giving carriers a life-long resistance to most strains of HIV.
About 1 per cent of Europeans have the mutation, but people of African, Asian and South American descent almost never carry it.
Though bone marrow transplants are not an effective therapy, since they are expensive and kill up to 30 per cent of recipients, it offers hope that AIDS patients' cells could be re-engineered using gene therapy.
US expert David Baltimore, who won a Nobel prize for his research on cancer viruses, described the breakthrough as "a very good sign'' and virtual "proof of principle'' for gene therapy cures,
Though the case has provoked great excitement, most experts are likely to remain wary until it is published in a peer-reviewed journal.
Will Nutland, from the Terrence Higgins Trust, said: "This give researchers a new avenue to explore but it should be remembered that we do not know what will happen to this patient in the long-term and that this has only been tried in one person.
"Also, if it is a breakthrough it will be a breakthrough in decades rather than years."
He added that HIV could remain in the body at undetectable levels for years.

Well this is all about the news :
I promise every one of you every time when I write for you all regarding HIV AIDS treatment and ongoing research on Vaccine and anti AIDS drugs that , "one day there will be a sure shot a definite a guaranteed treatment will be available for AIDS" !.
Till then hold on , HIV positive person should take medicines properly and regularly ,so that he saves his life.
Read my earlier post you will find even the latest treatment of AIDS by chemotherapeutic drugs has become very promising and a individual affected can live for longest life.
All should keep on reading this website .
As in this world I feel this website is the only place for the millions affceted who will definitely find relief and lots of hope for life. as here are all latest research and developments ongoing research on HIV AIDS.
i have writen about accidental HIV infected nedeel prik and its treatment.
HIV AIDS prevention steps ,i believe in living this life as it comes to us be it HIV positive ,or poverty we will live our life very strongly.
as i am sure that one day we will be having a latest to latest sure guarented a life saving treatment for AIDS and for HIV positive peoples can can have better life in coming days ,
sitll i am of the opinion that .
it is better to easy to prevent hiv virus from entering in our body by simple preventive steps for HIV measures in life rather than providing latest treatment for HIV positive .

Bone Marrow Transplant treatment to HIV positive suffering from leukemia
Gero Hütter etal --->

Question and Answers about HIV Testing -->

Signes and symptoms of AIDS and HIV infection-->

Basic Information about HIV and AIDS ==>



Pharma Process Validation

Keep reading this blog to find all sorts of information on HIV virus and information on AIDS.
Information about AIDS medicine
What is the latest treatment for AIDS HIV,
AIDS symptoms SYMPTOMS OF HIV HIV symptoms
What is current research and development over HIV AIDS vaccine and Anti AIDS therapy treatment . Information on HIV virus AIDS.

Send this blog by email to your friends and dear ones to fight against HIV AIDS ,by doing so you are joining me in the fight Against HIV AIDS ,there is a link below every post as email this post you can use this for emailing this blog to your friends.

Last updated : 13-Nov-2008

Saturday, November 1, 2008

Information on AIDS ,HIV virus What should be done to treat HIV infection HIV positive individual|What is the best treatment available today for AIDS

What should be done to treat HIV infected HIV positive individual.?
What is the best treatment available today for AIDS .?
What will be a best treatment for AIDS in today’s time.?

Information about AIDS treatment ,
Information on AIDS for future development of and anti AIDS drug , antiretroviral drug

After an individual is infected of found infected with HIV it is very big blow on the entire family of that person, but don’t worry now , I know that we can give life to such individuals who are caught by this disease, it is true that the treatment is difficult but it is not impossible. Today we have certain drugs available to treat HIV infection are such that
HIV virus is almost undetected with the treatment of these drugs , I will brief about these drugs and I will also tell you what is the future of HIV AIDS research and AIDS treatment.

Medicines Chemotherapy for AIDS:-As soon as a person is found HIV infected of positive following drugs should be started immediately with doctors advice .
1.(Azidothymidine ,AZT+ Lamivudine ) Combivir (Reverse transcriptase inhibitors) and
Norvir-boosted Prezista has showed viral count to the extent that it is undetectable.
2. Maraviroc –This is a latest new drug available for treatment for AIDS yet to be available in market , there are lot of hopes from this molecule I hope they are fulfilled.
Maraviroc is a drug which inhibits HIV virus from entering the T-lymphocyte, the best level of protection.
3.HIV Virus attachment inhibitors ( Yet to be developed):-
This class of drugs are very important as they will provide a very effective, efficient and sure treatment for AIDS HIV infection ,
I have written in depth in my earlier post regarding the research and development of HIV Virus attachment inhibitors refer on this blog.

These antiaids medicines chemotherapeutic agents will definitely lower the count of HIV virus to the extent that it is not detected.
But this should not be stooped here ,but I will recommend further few immunological treatments with
what is latest treatment for AIDS?
Treatment of AIDS with neutralizing antibodies and TB vaccine flue vaccine:-
1.Anti TB vaccine which is a latest development recently developed.
As the main cause of deaths in HIV infected patients is Tuberculosis co infection,
If a individual is recently found to be positive he should be first given this anti TB vaccine so that the co infection do not develop mean while we can treat patient with above drugs
2. Flue vaccine: - Patients newly found positive should be given flue vaccine so that the are protected from common cold infections which will not aggravate the condition and keep infections under control.

2.Neutralising antibodies for HIV virus PRO 140 antibodies which are recently developed and are very effective in inhibiting virus from attaching to human T-lymphocyte .
If we combine these antibodies along with Maraviroc and combivir , I am sure that the virus load is almost goes to zero and persons life can be saved.

What happens when HIV virus is not detected after these treatments:-
HIV virus remains there in the blood stream , we should continue the treatment further with neutralizing antibodies and other drugs and ones we are able to maintain good CD4 count our body will try to develop its indigenous vaccine against the HIV virus which will impart immunity to our body , but there will be always a race between HIV virus and antibodies against the HIV virus , so it is very important to keep the CD 4 cells count higher.

What should be done to keep the CD4 Cells count higher:-
Use of beta-Carotine , it is found that beta carotene increases CD4 count ,
a carrot in daily ,meal is like a great medicine as it contains lot of beta carotene .
this aria of treatment for AIDS required lot of research and development
if we some mean are able to increase CD4 cells count this will be very help full in treating AIDS patients .

What is the future of Anti AIDS research and treatment:-

In coming 10 years this disease will be having a complete and assured treatment .
A person can leave a normal and a successful life .
There are depressions associated with this disease, so now one should not keep these depressions after reading this website.

What a person should do when he is detected HIV positive :-

He should start HAART, antiretroviral treatment Drug s Medicines immediately as it is shown that the early treatment increases life of a individual. One can actually live till these 10 years and further his complete life provided he do not get depressed and he keeps on taking treatment through his doctor


Question and Answers about HIV Testing -->

Signes and symptoms of AIDS and HIV infection-->

Basic Information about HIV and AIDS ==>

Garlic and protease inhibitor drugs

Beta Carotene in HIV infection

HIV and Smoking
I have written over this blog about Research and Development of

AntiAIDS vaccine

DNA vaccine for HIV AIDS
Personalized AIDS vaccine
HIV part vaccines,
What are symptoms of HIV infection
What is HIV virus, how it infects human
What precautions one should take to protect himlf from this disease
What should be done in accidental contamination, accidental needle prick with HIV virus
How to develop neutralizing antibodies against HIV virus

What is latest current treatment available for AIDS .
Keep reading this blog to find what is the latest treatment for AIDS HIV,
What is current research and development over HIV AIDS vaccine and Anti AIDS therapy treatment .Information of HIV virus AIDS.
current research and developments on anti retroviral drugs.
Information about AIDS
AIDS symptoms SYMPTOMS OF HIV HIV symptoms
Information about HIV
Information on AIDS
Information on HIV virus
Send this blog by email to your friends and dear ones to fight against HIV AIDS ,by doing so you are joining me in the fight Against HIV AIDS ,there is a link below every post as email this post you can use this for emailing this blog to your friends.

Last updated : 01-Nov-2008