Authored By: B. V Waghmare

Wednesday, November 19, 2008

What is AIDS|HIV virus|information on HIV |Will there be a complete cure for AIDS |What is HAART |What is life span of a individual infected with HIV

Friends looking at the questions which are asked to me constantly through lots of emails which i am receiving from all the corners of globe, i am going to answer all questions listed below regarding HIV AIDS.
What is AIDS ? What is HIV virus ?
Will there be a complete cure for AIDS?
What is life span of a individual infected with HIV ?
Will a person survive through out his life if he is found HIV positive and starts treatment early without missing his drugs ?
What is HAART ?
Why we can not develop a vaccine for HIV AIDS?
What are the difficulties for developing HIV AIDS vaccine ?
What is current latest development of Drugs for AIDS HIV ?
What is current treatment for AIDS ?
AIDS symptoms SYMPTOMS OF HIV HIV symptoms
What is latest treatment for AIDS what is ongoing research on HIV virus and AIDS treatment?
I am trying to answer all of these questions together in this post in short.
What is an AIDS? :
AIDS is a disease condition caused by infection of HIV virus, here the HIV virus infects human body part whose primary role in our body is to protect our body from all sorts of infection cough cold, fever and every infecting thing.
But since this protective system is under attack by HIV virus this system fails to protect individual from incoming infections and also from opportunistic infections.
You can read over this blog to know what opportunistic infections are over my earlier posts. What happens after is declared he is having AIDS:
The person’s body is under attack from several microorganisms, yeasts, bacteria and fungi, which results in condition of multiple infections.
What is life threatening part of AIDS?:
If an individual gets Tuberculosis it is a condition which has caused lot of losses of life
Can we save a life of person if he is diagnosed early?
Yes! Yes! We can.
A serious part of this disease is the trauma of having this disease.
But if an individual takes medication properly he can leave a better life.
For what types of medication is required for an individual , it totally depends on that individual what are the drugs which are effective in lowering HIV virus counts are given by continuous monitoring of lowering of HIV viral load.
Will there be a complete cure for AIDS?
My dear friends if any one today is telling some one that he can cure AIDS ,Then he is a great genetics scientist or a medicinal chemist who constantly visualizes the Mode of Acton of antiAIDS drugs or he is a FAKE.
Why I mentioned great genetics scientist or a medicinal chemist is that we can get cure rather a complete life saving treatment through these sciences.
Today we have chemotherapeutic agents (Silently™ (Maraviroc) which can bring viral load almost to non detectable lavel, and once we achieve this we can assure that a patient can live his normal life ,but he has to continue medication without compromising any thing.
In coming few years we are going to have a complete life saving treatment for AIDS, till then hold on live your life write to me!
How do you feel!
Engage your self in constructive work than thinking on what will happen to you.
One can live a complete meaningful life if he decides ,so decide it “you will survive’ and you will definitely survive .
Refer my earlier post about Dr Gero Huetter’s bone marrow transplantM, there are lots of hopes from his finding.
Why we are not able to develop a vaccine for AIDS?
We will be getting few vaccines in coming years which will provide prophylaxis for patients who are recently detected or who are more porn to get this infection, amongst this there is Personalized vaccine for AIDS refer my earlier post on Dr. Jean-Pierre Routy who has developed personalized vaccine for HIV AIDS which I am finding a prominent and promising vaccine for AIDS so far.
Its bit difficult to develop vaccine against AIDS HIV as the virus keeps on changing his identity from one individual to other , just imagine a thief changing his face every day so what you will do for that .
We have solution for every thing
How anti AIDS drugs are developed?
This part of my writing you will never find over any place around the world.
You will find it here only As I am a person who has written how we can develop an Anti AIDS drug, an effective anti retroviral drug way back before Zudovudine was developed, and surprisingly the molecule about which I had written in my college days came out in few years to treat the disease, so I was on correct track.
Today also I am providing very important information over this place, with the intention of developing an effective anti AIDS drug as soon as possible.

Thymineribonucliotide How these anti AIDS drugs act : There is only one difference in RNA and DNA that is a base Thymidine DNA contains thymidine and RNA contains Uracil . Picking up this difference if we develop analogous molecule which will act competitively for reverse transcriptase of HIV virus .It will block synthesis of all proteins and enzymes and DNA and this will kill HIV virus. This is an enzyme dependant mode of action and has lots of draw backs but the entire benefits over weighs on draw backs .


(5' position on Ribose sugar is placed with Azo moiety (-N=N) in place of (-OH ) hydroxyl of Thymine ribonuclieotide in our body it competes for Thymine ribonuclieotide as it is structurally similar which bring all similarities of action due to ionic and hydrogen bonding .)

Same principle was used in developing Acyclovir an antiviral drug which is used for herpis infection. Acyclovir is a Guanocine antimetabolite Guanocine is a Base which is a building block for DNA of a common virus (not of HIV virus) the ribose sugar in guanosine nucleotide is modified and replaced with a straight chain of carbon with a ester in between just to mimic ribose .

These Aniti AIDS drugs are as follows
ZUDOVUDINE Zidovudine Azidothymidine
Portmanteau inhibitors
Researchers have designed molecules which dually inhibit both reverse transcriptase (RT) and integrase (IN). These drugs are a type of "portmanteau inhibitors".
Which other drug is best candidate for future development

Taxol (paclitaxel) is a drug that interacts with microtubule proteins in a manner that catalyzes their formation from tubulin and stabilizes the resulting structures
Taxol was shown to bind to DNA and RNA at G–C, A–T, or A–U bases and the .The taxol–polynucleotide complexation is associated with a partial helix stabilization
This is one of recent finding .

Cre recombinase
It is a Type I topoisomerase from P1 bacteriophage which catalyzes site-specific recombination of DNA between loxP sites. This is used in Genetic recombination techniques and is termed as “Cre-mediated recombination”
Currently it is studied for knoking down the HIV VIRUS DNA from an active to inactive form of DNA which is inserted in human T-lymphocytes .
Its purely genetic engineering and has great promising future for this research.

What is HAART?
Its is Antiretroviral drugs are medications for the treatment of infection with HIV.
When several such drugs, typically three or four, are taken in combination, the approach is known as Highly active antiretroviral therapy, or HAART.
Best drugs are combined together and administered to patients with continues monitoring of HIV viral load or count, and the drugs best fit are given , these drugs have proved very valuable in current treatment for AIDS ,
latest treatment for AIDS:
This include prophylatic preventive measures by giving BCG vaccine to infected individual as early as possibel before he shows any symptom of AIDS,
i will write in detail in my coming post for what could be the best treatment for AIDS.

Keep reading this blog to find all sorts of information on HIV virus and information on AIDS.
What is the latest treatment for AIDS HIV,
What is current research and development over HIV AIDS vaccine and Anti AIDS therapy treatment .Information on HIV virus AIDS.

Send this blog by email to your friends and dear ones to fight against HIV AIDS ,by doing so you are joining me in the fight Against HIV AIDS ,there is a link below every post as email this post you can use this for emailing this blog to your friends.

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Last updated : 19-Nov-2008

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