Authored By: B. V Waghmare

Friday, June 4, 2010

Researchers say novel RNA interference and stem cell therapy could in the future be used to treat HIV

A novel stem cell therapy could be the future be used to treat HIV, say Professor Ben Berkhout.

Also we have written in Dec 2008 about stem cell therapy for HIV virus infection and AIDS over this blog

Here is a detailed news about actual things happening in this direction.
Professor Berkhout from the University of Amsterdam is studding and developing therapy , read in details here.

Here is the news published in 1-Apr-2010 about stem cell treatment for AIDS 

Scientist's are studying a novel approach that impart immune system an intrinsic defence mechanism against HIV virus.
(There is complete information about HIV virus on this website)
Professor Ben Berkhout explained While speaking at the Society for General Microbiology’s spring meeting in Edinburgh, how this novel approach will dramatically make quality of life and life expectancy better for HIV positive individuals where antiviral drugs are no more efficacious.

In the absence of an effective vaccine, daily administration of anti-retroviral drugs is the most effective treatment for HIV. However, low patient compliance rates combined with the virus’s ability to easily mutate has led to the emergence of drug-resistant strains that are difficult to treat.

Professor Berkhout from the University of Amsterdam is investigating a novel gene therapy that has long-lasting effects even after a single treatment. It involves delivering antiviral DNA to the patients’ own immune cells that arms them against viral infection. “This therapy would offer an alternative for HIV-infected patients that can no longer be treated with regular antivirals,” he suggested.

The therapy involves extracting and purifying blood stem cells from the patient’s bone marrow. Antiviral DNA is transferred to the cells in the laboratory, after which the cells are re-injected into the body. The DNA encodes tiny molecules called small RNAs that are the mirror image of key viral genes used by HIV to cause disease. The small RNAs float around inside the immune cell until they encounter viral genes which they can stick to like Velcro(tm). This mechanism, called ‘RNA interference’ can block the production of key viral components from these genes.

Transferring the antiviral DNA to stem cells would help to restore a large part of the patient’s immune system. “Stem cells are the continually dividing ‘master copy’ cells from which all other immune cells are derived. By engineering the stem cells, the antiviral DNA is inherited by all the immune cells that are born from it,” explained Professor Berkhout.

There is detailed information about HIV virus and AIDS prevention and education and treatments and vaccine research and developments on this website

This blog contains information about new findings about HIV virus , and AIDS.


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Last updated : 4-Jun-2010

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