Authored By: B. V Waghmare

Monday, January 19, 2009

Latest Information on AIDS HIV Symptoms of AIDS Symptoms HIV | Treatment for AIDS Information about stem cell treatment for AIDS HIV virus prevention

Introduction:
This website is a resource for providing latest information about AIDS and HIV Virus
HIV SYMPTOMS AIDS SYMPTOMS SYMPTOMS OF HIV TESTING FOR HIV TRANSMISSION INFORMATION ON AIDS TREATMENT HIV POSITIVE LATEST INFORMATION.
latest treatments as well as current ongoing research and developments on AIDS and HIV virus.
You will find VERY UNIQUE information about AIDS and HIV viris over this website
As this website is written by a Pharmacist associated with anti AIDS drugs and treatment development for providing best treatment for HIV positive peoples.
I request to you all that you should read this website once in your life as this is in the interest of your family and Nation and this beautiful world.
GO DOWN THIS PAGE AND READ ALL INFORMATION ABOUT AIDS

IF YOU DONT HAVE TIME , SEND A EMAIL OF THIS WEBSITE TO YOUR SELF AND YOUR LOVED ONES,
& READ THIS WEBSITE WHEN EVER YOU FIND TIME.
you will find important and latest to latest information on AIDS ,Information about HIV virus, information about current research on AIDS, information on Current research on HIV virus and AIDS vaccine research , information on AIDS treatment, Information on HIV virus infection prevention.Stem cell treatment for AIDS information on Stem cell treatment for AIDS
How to prevent Mother to child Transmission of HIV virus
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In today's post I will like to give some important and good information about the development on HIV and information on AIDS treatment as well as current research on AIDS
The scientists involved in research and development for AIDS medicines are probably is not resting at all in the fight against the AIDS,they are working day and nights.
This is what i feel and understand, world of research and development is working so hard to develop a possible life saving treatment for AIDS HIV.

And i am proud that, this website too is on the leading front
for providing logic and phylosophy to develop anti AIDS treatment and for providing latest to latest information about AIDS and HIV virus as well as on going research and developments.

This website is ahead of every one to take initiative for developing anti AIDS drugs,
by writing the basic principles of phylosophy by our Pharmacist auther , for developing anti AIDS treatment anti AIDS drugs and anti AIDS vaccines.


This website is on the leading front with hands together with our honourable scientists around the world.

This is not that ,the Ideas are generated in only my mind , but there are our thousands of scientists working on this line, so there are many ways but the destination is same , to achieve complete life saving treatment for AIDS.

I had written over this website on 20-Dec-2008.
well befor the news about stem cell treatment for AIDS was published over other websites
About the possibilities of using stem cell treatment for treating HIV positive individuals , and how to use the stem cells to treat HIV positive individuals.
Please refer this post by following this link ,
published on 20-Dec-2008 http://www.bvwaghmare.blogspot.com/2008/12/stem-cells-therapy-in-treatment-of-hiv.html I have written about stem cell treatment for AIDS ,HIV positive for providing life saving treatment AIDS patients.we have given the brief procedure for how to go about giving Stem cell treatment.
This procedure you will never find elsewhere on Internet.
As auther of this website is a pharmacist , and this is written by a pharmacist thinking day and nights to provide a life saving treatment for AIDS.
Well i am not the only one in this fight against HIV , but just see how this website is ahead of every one in fight against AIDS.

Refer the news coming about the development of
Stem cell treatment for AIDS on website below
which is published on 17-Jan-2009
http://www.telegraph.co.uk/scienceandtechnology/science/sciencenews/4276488/Stem-cell-treatment-could-fight-Aids.html
http://www.ndtv.com/convergence/ndtv/story.aspx?id=NEWEN20090080467
published on 18-Jan-2009
http://www.zeenews.com/sci-tech/health-medicine/2009-01-18/499696news.html
published on 18-Jan-2009

About
stem cell treatment for AIDS .

I respect these websites too,as these websites are most reliable and great one in their own , as we are providing the knowledge to the whole world about HIV AIDS ,eradication of HIV from this world.
I heartily congratulate Dr David DiGiusto, director of haematopoietic cell therapies at City of Hope Medical Centre in Duarte, California, for taking a very great steps as, stem cell treatment only has greatest hopes, when we are facing difficulties in developing vaccines , to provide treatment for AIDS,a life saving treatment for AIDS , HIV positive patients.

I Pray to God for giving him great success .

Dr.David DiGusto said there " he is looking forward this treatment to reduce the toxicity of chemotherapy for AIDS".

Dr.David DiGusto is thinking about genetically modifying gene of patients affected to provide a base of T-lympocytic cells which will be stable and very resistant to HIV virus.
This approach is great and hope we get life saving treatment developed with the noble hands of Dr.David DiGusto .

I have tremendous respects for the scientists working for finding a solution for HIV infection.
In coming days their name will be referred with great respect proud by the whole world , they are the real Heroes of this world.

When i was studying in college doing course of a Pharmacist , i actually written about developing a anti AIDS drug where in i had written about replacing 5'-OH group of Ribose of Thymidine with -N=NH, so that it is taken up by HIV virus instead of tymine ,resulting competitive blockage of building block of RNA,
and similarly the same molecule the Azidothymidine (Zudovudine) AZT came in to reality for use as anti retro viral drug next year after that.

I know i am not only person thinking on this , there are others too ,In India we lack facilities for research .

I have written over this website in detail about other chemotherapeutic agents development , which molecules , and how , they could be best candidates as anti AIDS drugs, which will stop , inhibit, growth of HIV virus .

There is a other example too, where this website is well ahead to others providing information about AIDS and HIV virus.

A
s we are thinking like wise as these scientist are thinking to provide life saving treatment for AIDS .
Where I had written about on 5-dec-2008 on this blog
And Now there is good news that , a biotechnology company based in California Sangamo BioSciences Inc. has released a news in came in press on--> Monday 02-FEB-2009,--->http://www.reuters.com/article/healthNews/idUSTRE5116DT20090202


That they are going to start human testing of a new approach to treating patients infected with HIV the AIDS virus this treatment involves intentional alteration of the patients DNA.
This approach is based on findings of research which has shown that people with a certain mutation in a gene called CCR5 have capability to resist incoming infection of HIV virus and thus protects those peoples from AIDS.
This gene controls the entry of HIV virus in to the human T-lymphocytes , through receptor in immune system cells. Human immunodeficiency virus HIV virus uses the CCR5 receptor to get in to the cells T-Lympocytes and damages these cells.
Sangamo's drug SB-728-T disrupts CCR5. It is a zinc finger nuclease -- a compound that can slice open molecules.
This molecule is specifically designed to disrupt CCR5. Sangamo is planing to remove immune cells called CD4 T-cells from HIV patients, and treat them with this drug and re-infuse them in to patients.
There is a hope that these damaged cells will thrive and multiply and give the patient an immune system resistant to HIV virus.

"This will be the first time that we have the ability to make A HIV positive patients T-cells permanently resistant to incoming infection of HIV virus by CCR5-specific strains of HIV and we are very excited to begin a clinical trial of this novel zinc finger nuclease-based therapy," said Dr. Carl June of the University of Pennsylvania School of Medicine,
Who is going to help test patients recruited in trial.


The Sangamo said its phase I study is targeted to observe the safety only, and 12 patients with advanced HIV infection will be recruited by Sangamo.

"This approach has the ability to protect immune cells from infection with HIV and the expansion of CCR5-modified T-cells has the potential to provide long-term control of both the virus itself and eventually the opportunistic infections characteristic of AIDS," Dr. Carl June said.

Individuals interested in participating in this trial should visit http://www.clinicaltrials.gov/ or contact Larisa Zifchak, R.N. at 215-349-8091 .

In November 2008 , A German researchers Sergeon Dr Gero Huetter reported that his a bone marrow transplant sergery ,of a HIV positive patient with leukemia had treated his cancer, and also There was no HIV virus detected for two years .The transplant was from a donor who had the CCR5 mutation of a normal HIV negative donor.
I have written over this blog about.
How Chemotherapeutic drugs are developed to treat HIV virus infection

Lastly i will like to add the favorite quote of this website

"It is very easy to prevent spread of HIV AIDS by simple preventive measures rather than providing a treatment for AIDS and finding new drugs for fighting AIDS"

So educate every one , your dear and near ones for preventive steps followed for life for protecting them from HIV AIDS.
Please ready carefully information on AIDS , Information on HIV given below

How HIV virus is transmitted?
An Individual who is tested positive for HIV carries HIV virus in certain body fluids like blood, semen, vaginal secretions, and breast milk and serum( watery secretion which come out from small cuts which do not contain blood cells).
HIV virus is transmitted only if such HIV-infected fluids come in direct contact with the blood stream of another person who is not HIV positive.
This kind of direct entry can occur if
1.Through the of the vagina, rectum, mouth, and the opening at the tip of the male sex organ;
Unprotected sexual intercourse should be avoided.

Condom just makes risk of getting HIV transmission lesser ,they do not assure completely ,so what one should do is to avoid sex with unknown person or HIV positive individual.


2.Through intravenous injection with a syringe,sharing needles or syringes with someone who is HIV infected.
You don’t know who is having infection so do not use a used needles or syringes
3. Through a broken skin, such as a cut or sore, soar in mouth ,bleeding gums .
HIV is transmitted through:Infection during pregnancy, childbirth, or breast feeding—known as mother-to-child transmission, consult your gynecologist and find how you can protect your child from this in today’s world it is completely possible only thing is that you have to give so much attention to it.
If you are HIV positive and you are pregnant, you can protect you child from getting HIV by chemotherapy.

How HIV is not transmitted.
HIV virus is very fragile , it get killed by even strong sun light, if it is in open air.
It is not transmitted through food or air , (coughing or sneezing).
A person don't get infected by a household member, relative, co-worker, or friend through casual or everyday contact such as sharing eating utensils or bathroom facilities, or through hugging.

HIV is transmission through deep or prolonged "French" kissing, due to broken mucus membranes,bleeding gums.
You can not get HIV from giving blood at a blood bank or other established blood collection center
Sweat, tears, and urine do contain HIV virus so one should take a proper care.
Lastly you should fight against HIV virus , and not against infected individual.
you should provide all possible help to HIV positive peoples , this is the way we protect this world from AIDS.
I saw a movie today "Life support" by Nelson George.
The end of this movie was very touching the Queen Latfiah and every one reliving balloons in skies for lost dear ones ,

I felt I should stand tel every one that " we don't want a single life to be taken away by this HIV virus"
I am writing over here with the intention of sharing my knowledge and information on AIDS HIV with the scientist, Doctors around the world to help develop life saving anti AIDS drugs ,vaccines for HIV.

What makes it difficult for HIV positive to loose life is the lack of confidence .
So take chemotherapy properly and you are going to survive,

Information on AIDS Information about HIV virus mother-to-child transmission
Preventing Mother to Child Transmission of HIV virus.


Mother is the most precious thing in this world.

A female who is a mother , who is a wife and sister and a care taker in all relations
Each one of us is dependant on a women , she is mother.
hence other way women's are the care taker of this world.
and if we are not able to protect them from HIV what will happen to this world ?
If we are able to protect all women's from this disease we are won the battle against this virus.
If a women is HIV positive then it is best to avoid pregnancies
If a HIV positive women is pregnant the she should consult her doctor immediately.
Best thing is to start combination anti retroviral therapy .
This reduces the risk of HIV virus transmission from mother to child .

Recommended anti retro viral drugs regimen for preventing mother to child transmission of HIV virus (PMTCT) is use of combination of AZT and single dose nevirapine.
Woman should start taking AZT after 28 weeks of pregnancy (or as soon as possible thereafter).
During labour she should take AZT and 3TC, as well as a single dose of nevirapine.(Please consider drug resistance factor)
Her baby should receive a single dose of nevirapine immediately after birth,
Followed by a seven-day course of AZT. The mother should continue taking AZT and 3TC for seven days after delivery, to cut the risk of drug resistance still further.
This is a prophylactic treatment and does not completely ensure complete safety against HIV virus transmission from mother to child but has given good results .
(I HAVE WRITTEN FOR PURPOSE OF AWARENESS .YOU SHOULD NOT USE ANY DRUG, OF YOUR OWN WITH OUT CONSULTING YOUR DOCTOR AS THERE ARE LOT OF FACTORS TO BE CONSIDERED LIKE DRUG RESISTANCE HENCE CONSULT DOCTOR )

I will like to recommend research and development scientists and Doctors working on Preventing mother-to-child transmission to make use of immunoglobulines
(latest HIV Antibody treatment) along with antiretroviral combination therapy chemotherapy.
After birth care for preventing HIV virus mother-to-child transmission.
1.Avoid breast feeding , though mothers milk is best for a new born child , breast feeding should be avoided by a HIV positive mother.
Infants should be given infant formulas , infant nutrients rich feeds,
Best is the bottle feeding milk of a HIV negative mother (WET NURSE) .
There are methods to make the milk free of virus , these are required to be tested and proven (trials).
(Mothers milk is the best food for infant , but in case of HIV positive , mothers milk may contain HIV virus , and This virus may get in to infant by oral route even if mother is taking anti retro viral drugs.)

We have hopes that we will soon get life saving treatment for this HIV AIDS in coming 5 years.

(I am not mentioning cure ,rather there will be complete life saving treatment for AIDS, we will be able to save life through out ones life)

One can live his life by taking available anti AIDS drugs and medicines and live his entire life.
We have now almost very promising drugs available , one should consult doctors, listen to them properly and follow them.
What it makes difficult to live life for HIV positive is the love and support of this society.
As i always believed in achieving difficult things , but i do achieve ,and this time,I want to achieve social awareness about HIV AIDS so that this disease is eradicated from this world.
After an individual is infected of found infected with HIV it is very big blow on the entire family of that person, but don’t worry now ,
I know that we can give life to such individuals who are caught by this disease, it is true that the treatment is difficult but it is not impossible. Today we have certain drugs available to treat HIV infection are such that HIV virus is almost undetected with the treatment of these drugs , I will brief about these drugs and I will also tell you what is the future of HIV AIDS research and AIDS treatment.
AIDS Medicines,Chemotherapy for AIDS:-
As soon as a person is found HIV infected of positive antiretroviral drugs should be started immediately with doctors advice
(I am giving examples of drugs for your information only and these requires to be given in different ways person to person as there are resistance factors involved with the drugs so follow your doctors advice strictly)
1.(Azidothymidine ,AZT+ Lamivudine ) Combivir (Reverse transcriptase inhibitors) and Norvir-boosted Prezista has showed viral count to the extent that it is undetectable. 2. Maraviroc –This is a latest new drug available for treatment for AIDS yet to be available in market , there are lot of hopes from this molecule I hope they are fulfilled. Maraviroc is a drug which inhibits HIV virus from entering the T-lymphocyte, the best level of protection.
3.HIV Virus attachment inhibitors ( Yet to be developed):- This class of drugs are very important as they will provide a very effective, efficient and sure treatment for AIDS HIV infection ,
I have written in depth in my earlier post regarding the research and development of HIV Virus attachment inhibitors refer on this blog. These anti AIDS medicines chemotherapeutic agents will definitely lower the count of HIV virus to the extent that it is not detected.
But this should not be stooped here ,but I will recommend further few immunological treatments with
what is latest treatment for AIDS?
Treatment of AIDS with neutralizing antibodies and TB vaccine flue vaccine:-
1.Anti TB vaccine which is a latest development recently developed. As the main cause of deaths in HIV infected patients is Tuberculosis co infection, If a individual is recently found to be positive he should be first given this anti TB vaccine so that the co infection do not develop mean while we can treat patient with above drugs
2. Flue vaccine: - Patients newly found positive should be given flue vaccine so that the are protected from common cold infections which will not aggravate the condition and keep infections under control.
3.Neutralising antibodies for HIV virus PRO 140 antibodies which are recently developed and are very effective in inhibiting virus from attaching to human T-lymphocyte . If we combine these antibodies along with Maraviroc and combivir , I am sure that the virus load is almost goes to zero and persons life can be saved.
What happens when HIV virus is not detected after these treatments:-
HIV virus remains there in the blood stream , we should continue the treatment further with neutralizing antibodies and other drugs and ones we are able to maintain good CD4 count our body will try to develop its indigenous antibodies against the HIV virus which will impart immunity to our body , but there will be always a race between HIV virus and antibodies against the HIV virus , so it is very important to keep the CD 4 cells count higher. What should be done to keep the CD4 Cells count higher:-
Use of beta-Carotine , it is found that beta carotene increases CD4 count , a carrot in daily ,meal is like a great medicine as it contains lot of beta carotene . this aria of treatment for AIDS required lot of research and development if we some mean are able to increase CD4 cells count this will be very help full in treating AIDS patients .
Stem cell Therapy for HIV positive patient :-
(Dr.David DiGusto)
If this is developed sucessfully then we can treat HIV positive individual with stem celss which will generate T-Lymphocytic celss in his body which are resistant to HIV virus entry in them , that way they will be resistant to HIV and produce antibodies against HIV viurs and kill HIV virus (Auto Vaccine) have you heard of auto immunity ,auto immunity brigs some damage in our body but auto vaccine will provide protection against HIV virus.
What is the future of Anti AIDS research and treatment:- In coming 5 years this disease will be having a complete and assured life saving treatment . A person can leave a normal and a successful life . There are depressions associated with this disease, so now one should not keep away these depressions.
This is not only my opinion but also of the great scientist who discovered HIV virus and who was honoured with NOBLE award too says this.
What a person should do when he is detected HIV positive :-
He should start HAART, antiretroviral treatment Drugs ,Medicines immediately as it is shown that the early treatment increases life of a individual. Do not get depressed and he keeps on taking treatment through his doctor. keep aside dipression , worries and depressions brings damages than any good thing, so why it should be in our life? kike it out.


Join me in the Fight Against HIV AIDS just by Emailing this website to your near and dear friends and family members.


Mr.Nelson George Director of movie "Life support". If you can see this movie







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This website is developed and maintained to provide latest to latest information on current research on AIDS current research on HIV information on AIDS Information on HIV virus infection




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Sporce:



Question and Answers about HIV Testing -->http://www.cdc.gov/hiv/topics/testing/resources/qa/index.htm

Signes and symptoms of AIDS and HIV infection--> http://www.aids.gov/hiv-aids-basics/hiv-aids-101/overview/signs-and-symptoms/

Basic Information about HIV and AIDS ==>http://www.cdc.gov/hiv/topics/basic/index.htm
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You will find all information about HIV virus ,complete and detailed information on AIDS ,and HIV virus,complete information about Latest treatment for AIDS, and on following topics over this blog .
YOU JUST HAVE TO FIND THAT ON BLOG POST
HIV SYMPTOMS AIDS SYMPTOMS OF HIV TESTING HIV TRANSMISSION INFORMATION ON AIDS TREATMENT HIV POSITIVE LATEST INFORMATION
WHAT YOU HAVE TO DO IS FIND IT ON BLOG ARCHIVE ON RIGHT HAND SIDE OF THIS WEBSITE
Latest treatment for AIDS,
How a anti AIDS Drug ,chemotherapeutic drug for AIDS can be designed

What are the difficulties in developing vaccine for AIDS against HIV virus.
what are the latest anti AIDS drugs
Current research and developments on anti retroviral drugswhy there is no vaccine for HIV AIDS.
A Detailed
information on HIV virus is there on this blog.
A Detailed
information on AIDS is given on this blog.
A Detailed information about AIDS About HIV Virus is given on this blog.
What are the preventive steps for protection against HIV virus
What are the current research and developments on HIV virus, vaccine for HIV virus AIDS, and Latest treatment for AIDS.
Making use of genetic engineering for providing life saving treatment for AIDS. Gene therapy for AIDS.

Stem cell therapy for AIDS ,using basal stem cells treatment for HIV positive individual.
Research on new drugs for HIV AIDS.Every thing about AIDS HIV virus.

latest research on AIDS.
latest research on HIV
Information about HIV virus.
Information about AIDS.
what is current research on AIDS
What you have to do is search over this blog you will find detailed information on AIDS,
Information on HIV virus.and HIV vaccine research a life saving latest treatments available for AIDS.
Information about AIDS medicines
important information on AIDS treatment
important information on HIV virus
Latest Information on AIDS treatment
Information about stem cell treatment for AIDS
Information on AIDS
Information on AIDS prevention
HIV virus infection prevention
Information about HIV Virus AIDS symptoms


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This website provided complete information about hiv virus , hiv infection , early hiv symptoms , hiv treatment, HIV test and hiv testing centers, aids symptoms, symptoms of hiv immideately after infection.

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After birth care for preventing HIV virus mother-to-child transmission.




Last updated: 19-Jan-2009



Thursday, January 15, 2009

HIV-1 drug resistance assay,HIV Information on AIDS|antiAIDS drugs|Information about AIDS medice precise use of anti AIDS Drugs,doing resistance assay

Dear friends i am regularly writing on this blog about latest treatment for AIDS HIV positive and a latest information on HIV virus and Information on AIDS and going research and development on anti AIDS Drugs and anti AIDS HIV vaccines ,i am going to give you here the best information about AIDS medicines,best to best treatment for AIDS.

Today i am going to give you very valuable information on HIV anti aids drugs about

How we can make effective and precise use of available anti AIDS Drugs chemotherapeutic agents ,by knowing which drug is not effective against the virus present in infected individuals body.

This can be achieved by knowing resistance developed by HIV AIDS virus against a particular anti AIDS drug.
Drug resistance means the drug is not giving desired effect on HIV virus , that is HIV virus has developed protective mechanism against this anti AIDS drug.
we all know as and when we are using one particular drug against particular infection ,due to biochemical factors and continues usage of these drugs the bacteria or a virus develops resistance against the drugs being used , rendering these drugs less effective.
Same thing happens with HIV virus
we keep on administrating anti AIDS drugs but on prolonged time HIV virus develops a drug resistance against particular anti AIDS drug

well but there is a technique to over come this drug resistance
this is a purely scientific technique that is to map the Gene on of HIV virus from infected person to find out the all possibilities and any mutation, as mutations are the main cause for drug resistance.
This technique is called HIV -1 drug resistance assay.

The current genotypic PCR based assay amplify and sequence the protease gene and reverse transcriptase gene they are not always able to detect HIV -1 M subtype

most reliable could be Viroseq (Abbot Diagnostics USA)

Some companies in INDIA has developed their own HIV-1 drug resistance assay ,indigenous methods which are very reliable .
This company uses spin column based kit rather than imported ones available in the market its one step reverse transcription kit is routinely used to transcribe the protease and Reverse Transcriptase gene of the HIV viral genome to DNA to make it amenable to polymerase chain reaction.This reverse transcription and subsequent PCR is done by a single tube reaction using a highly convenient one step RT-PCR process using the in house developed kit.
One of the important feature of this assay is availability of back up RT PCR primers .these primers are used when drop out specimens are encountered that fail to respond to the first pairs , these HIV drug resistance assays are capable of scanning 100 codons of protease gene.
A HIV drug resistance interpretation report provides important information on HIV drugs, anti AIDS drug resistance profile of drugs like Nucleoside Reverse Transcriptase inhibitors ,Non Nucleoside Reverse Transcriptase inhibitors , Protease inhibitors .

The HIV Drug resistant assay developed in INDIA provides A SCORING VALUE INDICATION LEVEL OF RESISTANCE AGAINST EACH ANTI AIDS DRUG by a particular HIV virus isolated from infected individual.
This report is very use full tool to decide which drug regimen should be continued for better results for against HIV virus infection. this will help us to bring down HIV virus load to significant lower level so that HIV virus is not detected in blood and semen .
which will definitely save liefs of HIV positive peoples.
About the author of this blog.
Author of this blog is a Pharmacist and he is associated in developing HIV AIDS vaccines and anti AIDS drugs with institute in USA.
This is a reason that you will find some information on HIV AIDS only on this blog and not elsewhere on Internet. This is one of the best information website for AIDS, HIV positive peoples, to find latest update on AIDS treatment, latest research and development over AIDS medicine, so that we can provide best treatment for AIDS , HIV positive peoples.

You can email this blog to your dear and near ones to whom you love most so as to make them aware of importance of preventive steps for HIV AIDS and information on HIV virus and Information on AIDS , by doing this you are joining me in fight against HIV AIDS.
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You will find following information about AIDS ,information about HIV virus on following topics on this blog ,
What you have to do is find that over blog Archive on right hand side of this blog.
Latest treatment for AIDS,
How a anti AIDS Drug ,chemotherapeutic drug for AIDS can be designed
What are the difficulties in developing vaccine for AIDS against HIV virus.
what are the latest anti AIDS drugs, current research on AIDS, current research on HIV virus
why there is no vaccine for HIV AIDS. A Detailed information on HIV virus is there on this blog. A Detailed information on AIDS is given on this blog.
A Detailed information about AIDS About HIV Virus is given on this blog. What are the preventive steps for protection against HIV virus What are the current research and developments on HIV virus, vaccine for HIV virus AIDS, and Latest treatment for AIDS. Making use of genetic engineering for providing life saving treatment for AIDS. Gene therapy for AIDS,information about AIDS medicines
Stem cell therapy for AIDS ,using basal stem cells treatment for HIV positive individual. Research on new drugs for HIV AIDS.Every thing about AIDS HIV virus.

AIDS symptoms
SYMPTOMS OF HIV
HIV symptoms
latest research on AIDS
latest research on HIV
information about AIDS medicines
what is current research on AIDS
What you have to do is search over this blog you will find detailed information on AIDS,Information on HIV virus.and HIV vaccine research a life saving latest treatments available for AIDS.


Information about HIV Virus AIDS symptoms

Source:
HIV-1 Drug resistance assay
http://www.ncbi.nlm.nih.gov/pubmed/15572008

Signes and symptoms of AIDS and HIV infection--> http://www.aids.gov/hiv-aids-basics/hiv-aids-101/overview/signs-and-symptoms/

Basic Information about HIV and AIDS ==>http://www.cdc.gov/hiv/topics/basic/index.htm



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This website provided complete information about HIV virus , hiv infection , early hiv symptoms , HIV treatment, HIV test and hiv testing centers, aids symptoms, symptoms of hiv immideately after infection.

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Last updated: 15-Jan-2009



Wednesday, January 7, 2009

INFORMATION ON AIDS HIV VIRUS|HIV AIDS Prevention Research and Development on AIDS vaccine and anti AIDS drugs| latest treatment for AIDS HIV POSITIVE

ANTI AIDS, HIV INFECTION TREATMENT,
WHAT WILL BE A POSSIBLE BREAKTHROUGH IN RESEARCH ON ANTI AIDS, HIV DRUGS
I AM GIVING HERE ALL POSSIBILITIES & BREAKTHROUGHS IN RESEARCH ON ANTI AIDS DRUGS.
IF YOU READ THIS WEBSITE THOROUGHLY YOU WILL GET ALL INFORMATION HIV VIRUS AND INFORMATION ON AIDS HOW HIV VIRUS INFECTS HUMAN
AND HOW TO PREVENT YOURSELF FROM HIV VIRUS.
YOU WILL FIND A VERY IMPORTANT AND UNIQUE INFORMATION ON HIV AIDS ONLY OVER THIS WEBSITE AS THIS WEBSITE IS WRITTEN BY A SCIENTIST WORKING ON VACCINE FOR HIV VIRUS AND ANTI AIDS DRUGS.
HE IS ASSOCIATED WITH ONE OF LEADING RESEARCH INSTITUTE IN USA.
WHAT ARE THE CURRENT MEDICINES USED FOR TREATMENT AND WHAT WILL BE THE POSSIBLE DRUGS FOR FIGHTING THIS DEADLY DISEASE
What is HIV?
HIV stands for Human Immunodeficiency Virus. HIV is the virus that causes AIDS. While many viruses can be controlled by our bodies immune system, HIV virus targets and infects the same immune system cells that are supposed to protect us from illnesses. These are a type of white blood cell called T-Lymphocytes. HIV takes over T-Lymphocytes cells and turns them into virus factories which intern produces thousands of HIV viral copies as HIV virus grows in number, it damages or kills T-Lymphocytes cells, weakening the immune system.
AIDS stands for Acquired Immune Deficiency Syndrome. AIDS is the most advanced stage of HIV infection. HIV causes AIDS by attacking the immune system’s soldiers – the T-Lymphocytes cells . When the immune system loses too many T-Lymphocytes , you are not able to fight any sort of infection and a simpler infection can develop serious, often to a deadly, infections. These are called opportunistic infections (OIs) because they take advantage of the body's weakened defenses. When someone dies of AIDS, it is usually opportunistic infections or other long-term effects of HIV infection that cause death.
AIDS refers to the body’s immune-compromised state that can no longer stop OIs from developing and becoming so deadly.
You don't have AIDS as soon as you are infected with HIV. You can remain HIV+ve for many years with no signs of disease, or only mild-to-moderate symptoms. But without treatment, HIV will eventually wear down the immune system in most people to the point that they develop more serious OIs. The Centers for Disease Control and Prevention (CDC) USA defines someone as having AIDS if he or she is HIV+ and meets one or both of these conditions:
Has had at least one of 21 AIDS-defining opportunistic infections Has had a CD4 cell count (T-cell count) of 200 cells or less (a normal CD4 count varies by laboratory, but usually is in the 600 to 1,500 range)
Most people can not tell that they have been exposed or infected. It can take up to 12 weeks for an HIV test to come back positive. However most people respond much faster. Within two to four weeks of exposure to HIV, you might have flu-like symptoms such as fever, swollen glands, muscle aches, or rash. The only way to know for sure if you are infected is take an HIV test. If you are infected, your immune system will make antibodies to fight the virus. The HIV test looks for these antibodies. If you have them in your blood, it means that you have HIV infection.
Do I Need to Get Tested for HIV?
The CDC estimates that more than 25% of HIV+ people are unaware of their HIV status. Many of these people look and feel healthy and do not think they are at risk. But the truth is that anyone of any age, gender, race, sexual orientation, or social or economic class can become infected. It is your actions (or the actions taken against you), that put you at risk. You should be tested if: You have had vaginal, anal, or oral sex without a condom You have shared needles or syringes to inject drugs (including steroids or hormones) You are uncertain of your partner’s status or your partner is HIV+ve. You are pregnant or are considering becoming pregnant You have ever been diagnosed with a sexually transmitted disease You have hepatitis C Why Should I Get Tested?If you test HIV+ there are effective medications to help you stay well. But you cannot get the health care and treatment you need if you do not know your HIV status. Being unaware of your status also makes it more likely to unknowingly pass HIV to others. If you test HIV- you can take steps to stay that way. You can also spare yourself unnecessary worrying. What Tests are Available?The most common test for HIV is the antibody test (called ELISA). It can be done on blood, saliva, or urine. According to the CDC, it is more than 99% accurate. Results are generally available within two weeks. (There is a rapid ELISA test that gives results in less than half an hour.) A positive result means your body has developed antibodies for HIV, so you are infected with the virus. To be completely certain, positive results are confirmed with a more sensitive test called the Western blot. A negative result means your body has not developed antibodies and are probably not infected. To get truly accurate results, it's necessary to wait three to six months after your last possible exposure to the virus before being tested. That is because the immune system can take anywhere from three to twelve weeks to make antibodies. In this "window period," someone may get an unclear result or a false negative.

A BRIFE INFORMATION ON HIV VIRUS :
WHAT ARE THE CHALLENGES TO FIGHT AGAINST THIS VIRUS
HIV virus is a T -lymphocytic RNA Virus which is classified as Retrovirus , it uses RNA to as its source for genetic information, It do not contain its own DNA,where as it uses RNA for first forming a (DNA copy ) for its multiplication with help of reverse transcriptase enzyme, after it gets entry in hosts cell this is called reverse transcription (RNA TO DNA AND TO PROTEIN SYNTHESIS). The process of normal cell DNA multiplication is called trancription(DNA TO RNA AND TO PROTEIN SYNTHESIS). as protein synthesis and multiplication is a process only DNA can bring about.virus intercalates and instigates its (DNA copy ) in human DNA and thus , when ever our body , cell under goes multiplication or , it brings about protein synthesis for our body for normal metabolism , our cell by default also synthesizes Virus RNA ,and Virus proteins ,and these Viral RNA and proteins assemble together to form a new virus (Process of virus multiplication). The enzyme which help virus to Integrate its (DNA copy ) in Human DNA is Intercalase , for this (DNA copy ) to get proper place in Human DNA a enzyme , Ligaase , which cuts Human DNA at correct required Point . This point Varies in Person to person ,it will be different in different individuals and hence a mutation occurs in Virus DNA ,and newly Virus thus formed is different from original, which is mutation. These are the enzyme which has made this virus very deadly, as it moves from one human to other , its genetic code for protein amino acid sequence changes , and it makes difficult to establish a identity from one host to other ,consider it as a mutation from one virus to other. that is the reason why we are not able to produce vaccine for this. as there are challenges there are solutions,
WHAT ARE THE SOLUTIONS .....the author of this blog is a Pharmacists and these are his views which are fundamentals for today's research and dvelopment going on HIV AIDS Vaccine anti AIDS drugs ,and Personalised HIV Vaccine ......
Virus Has a unique way of infecting host cell, that is through CD4 RECEPTOR over T -LYMPHOCITC CELLS (a main part of human body to provide immunity against any sort of infection) hence method of attachment to CD4 receptor is same , hence we can possibly identify the sequence of amino acid in the protein coat over counter part on HIV virus which attaches to CD4 RECEPTOR, This protein sequence can enable us to develop a part of protein of virus and we can use this as a VACCINE , .......This is what is currently happening for part vaccines ...dendritic cells ..antigen presenting to novice body..
HOW IS THE CHEMOTHERAPY DESIGNED ?
HIV VIRUS contains RNA ,and our body cells contain DNA, and only key difference in both, is a Nucleotide Thiamine Trineuclio Phosphate , if we are able to stop , usage of this nucleotide by virus , eventually we can stop virus reproduction, and growth of virus as RNA for next virus is not synthesized there by stooping growing and will stop killing our body defence mechanism.
This is what is done by available medicines like Azidothymidine, Zudovudine, same way virus multiplication can be hampered by using Uracil anti metabolite , where you can incorporate -N=NH moiety like in zudovudine and it can survive as DNA elongation step inhibitor. it may be equally harmful to Patients body beyond some extent. Hence combination Therapy ,which will help take care of infective process of virus at all stages of infection has to be blended together, Drugs should be combined to, 1.Genetically engineered CD4(Partial Vaccines):- Here we can Design CD4 receptor in vitro (genetic engineering) and these engineered receptor will get targeted by virus and there by make it loss its RNA in serum before entry in host cell.
2. Drugs which inhibit attachment :- eg:- amantadine
3. Drugs which will hamper integration of PRO VIRUS TO HUMAN DNA . URACIL ANTI METABOLITE,
4. Reverse transcriptasae inhibitors
virus synthesizes its DNA from RNA
(THIS IS CALLED REVERSE TRANSCRIPTION)
in host cell after geting in host cell eg:- AZIDOTHYMYDINE.
5.Intigraese inhibitor:-these drugs are under development and are suppose to inhibit Pro virus DNA to integrate in o Human DNA. 6.Immunoglobulines :-They Surround HIV virus and its components , and neutralize its activity.
6:- Poly -Poly units:- eg :- poly -ala.(POLY ALANINE)
Inhibits reverse transcription,And intigrasae.by forming a back bone Hydrogen bonding with cDNA strands in process of replication , and thus Reverse-transcription,and Transcription is inhibited.
This group of molecules are extensively required to be studied for the anti retro viral activity
Combination of all step inhibitors will give good result.
There are other many drugs which are required to be tested To know in detail about aids HIV drugs used on HIV aids read this blog in detail.

I have written all information about HIV VIRUS & AIDS and i have written about HIV AIDS treatment. and about following topics.
Why it is difficult to develop a vaccine for HIV AIDS
What are the current mode of treatment for HIV AIDS
What should be done in of accidental contact with HIV infected object
what is current research on AIDS
What are the current drugs which are effectively used for treating HIV positive individuals and AIDS.
What should be the approach for research and development of anti AIDS drugs and vaccine.
Is there possibilities for complete life saving treatments by genetic engineering and gene therapy
What is latest treatment for aids HIV available,information on HIV virus and Information on AIDS
What precautions are required to be taken by every one so that he is not infected by HIV virus
You will find answers for your all questions about HIV virus and AIDS, information on HIV virus and Information on AIDS
Information about AIDS medicines
AIDS symptoms
SYMPTOMS OF HIV
HIV symptoms
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and send this blog to all of your friends and dear ones by email so that you help them to protect them against this disease.
Information about HIV Virus AIDS symptoms
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Source:

Question and Answers about HIV Testing -->http://www.cdc.gov/hiv/topics/testing/resources/qa/index.htm

Signes and symptoms of AIDS and HIV infection--> http://www.aids.gov/hiv-aids-basics/hiv-aids-101/overview/signs-and-symptoms/

Basic Information about HIV and AIDS ==>http://www.cdc.gov/hiv/topics/basic/index.htm

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Last updated: 07-Jan-2009



Saturday, January 3, 2009

HIV VIRUS NOT DETECTED IN BLOOD BUT DETECTED IN SEMEN |A ARTICLE ON NFORMATION HIV VIRUS AND INFORMATION ON AIDS | Information about AIDS medicines

HIV VIRUS NOT DETECTED IN BLOOD BUT DETECTED IN SEMEN
I came across a research study where in it is found that five percent of HIV-positive individuals in a French study had detectable HIV in their semen even when no HIV virus is detectable in their blood, says researchers ,
Declared it nearly impossible for an HIV positive person with no sexually transmitted infections (STIs) and an undetectable viral load in blood for at least six months to transmit HIV to an uninfected sex partner.

To provide an accurate view of the HIV transmission risks for serodiscordant couples—where one partner has HIV and the other does not—who want to have children through natural conception. Currently, the only recommended method of conceiving a child for couples where the man is HIV positive and the woman is HIV negative is artificial insemination with semen that is proven free of HIV.

To determine the possible risk of HIV transmission for serodiscordant couples, Anne-Genevi√®ve Marcelin, PharmD, PhD, from the Universit√© Pierre & Marie Curie in Paris, and her colleagues examined paired blood and semen samples from 145 HIV-positive men who had used the services of an assisted reproductive agency in France. Some of the men gave multiple samples over time, so Marcelin’s group was able to compare 264 paired samples in all.
Marcelin’s team found that the amount of virus was almost always consistent between blood and semen samples. In 85 percent of the paired samples both the blood and the semen had undetectable levels of HIV. In 3 percent of the samples, both the blood and semen had HIV present. Seven of the 145 men, however, did have detectable virus in their semen, but none detectable in their blood sample. All of the men were on a stable antiretroviral (ARV) therapy regimen, and none had an STI. The men were also taking a wide variety of ARVs, including those known for getting into seminal fluid. All of them were also later able to provide a semen sample that was undetectable for HIV.
The authors point out that these men could have infected their female partners if they had attempted conception through unprotected sex when they had detectable virus in their semen, but not in blood. The researchers give several reasons for possible fluctuations in seminal HIV levels, including undetected STIs, adherence challenges and ARVs that fail to penetrate seminal fluid. Other reproductive specialists who work with serodiscordant couples have pointed out that prostate or urethra inflammation, which may not be due to any infection, could lead to increased HIV production, even in the presence of ARV drugs.

Finding of this study is very useful to provide latest to latest treatment for AIDS , by even testing periodically seminal viral load of an HIV positive individual.

Source:


Basic Information about HIV and AIDS ==>http://www.cdc.gov/hiv/topics/basic/index.htm





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Last updated : 03-Jan-2009