Effect of nicotine over anti AIDS drugs

Tobacco contains alcoloids one of them is known as Nicotine. Nicotine  has many worst side effect on human body.
It acts on  brain  and causes  depression , in long term use .

Many drugs degradation occur through one or the othere degradation path way as that of nicotine.
Thus intake of tobacco , is responsible for elevated enzyme levels which are responsible for degradation of these drugs .

One example of enzyme which is elivated is cytochrom p450.
This is because of metabloic load on liver .
Many anti AIDS drus are antimetabloites , or enzime inhibitors , like , Protease inhibitors and Reverse transcriptase inhibitors .
There is a common site on Anit AIDS drugs and  Nicotine for all enzime actions like ,Blocking certain Enzymatic activity, Enzyme oxidation , or transamination , acetylation , or DNA polymerisation.

Thus nicotine may render anti AIDS drug less effective in patients who are smokers or use tobacoo , in one or the other form.

i will add more information in coming days on this topic .

This is true for all drugs , excepts few of them whos actions are agonistic with nicotine , the action is vasodialation .
fainting , and so on , which again are not desired .

I have tried to keep this article as small as possible , but this one is a biger topic , i will update tis topic over the time.

I have come across a new research and development in treating HIV positive peoples . i will write over this blog in coming time , which is going to be one of the best treatment for AIDS.


So say no to tobacco and smoking.

Qute smoking join in the mission against smoking and Gutkha . Save future of Childrens

Tobacco is one of the thing which has paralised mankind worldwide.


If you are smoking ,chewing , or consuming tobacco in any form , then keep in mind that you are poisoning your brain.

Effect of smoking on our Brain
It first increase the stimulation in brain , it gives you , a feeling of wellbeing , but after smoking after an hour or two  , tobacco exactly works in reverse manner....It will bring depression in your brain.....It will make you less confident.....It will make you forget many important tings which are essential to become sucessful in Job , Bussiness , and personal life too.

Why there is feeling of wellbeing?
Tobaco contains a alcaloid called as Nicotine ...It mimiks all activities of a neuro trasmeter in brain like noradrenaline and adrenaline.
This brings about initial stimulation in our brain.

Why It Gives Dipression after few hours of smoking.?

As nicotine is not a true neuro trasmeter , our body develops a feed back mechanism to counteract its stimulation activty .
This leads to a state of dipression after some time after smoking , where a person is not able to do his work normaly.
This is where dwonfall starts for mankind.
Peoples dont like to understand or know  these biochemichal changes which occures in our brain. The cigarte that you are smoking is giving pleaure for a munite , and making your brain a less functional , than before smoking.

The same things happen when tobaco is consumed in any other form , like gutkha , pan etc.

This effect is causes a loss to an individual .
He becomes unsucessful in his carrier , in his life , apparently he may be sucessful but really if you ask a smoking guy , they will tel you exactly the same thing that i am writing here.

This cause loss to our nation and mankind , families .

I have decided to start a drive to educate peoples and ask every one to stay away from smoking , gutkha , and tobacco.

I have a dream ,  i want to see a world where no one will make use of tobacco , or smoke a cigarette , or chew Gutkha.

Realy gutkha has become a curce for India , every college going youngster and kids are traped in to the habit of chewing gutkah amd , cigarete smoking.

We anounce that we have a mission , to educate , peoples for living healthy life , where there is no place for smoking , and Gutkha.

We will ask peoples to quite smoking.

We will educate students for staying away from Gutkha.