Authored By: B. V Waghmare

Wednesday, October 1, 2008

Genetics Research Advances Possibility of HIV Vaccine

Genetics Research Advances Possibility of HIV Vaccine
Today I am writing some important research findings on HIV AIDS vaccine research .I am always optimistic regarding future of HIV vaccine and surly some day we will be successful get this , and reason why I feel that we are marching ahead with detailed studies about virus , and here is reference for HLA-1 can be genetically mapped and engineered , and this can be used as a part vaccine. Read further this website you will be assured of this, as this place you will find what is going on HIV AIDS research and drugs which are being currently used to treat this disease.
Study conducted at Massachusetts General HospitalHIV Vaccine Research has discovered how the HIV virus escapes the human body’s immune system.
The research collaborative - involving scientists from the British Columbia Centre for Excellence in HIV/AIDS, Massachusetts General Hospital (MGH), Microsoft Research and Los Alamos National Laboratory - used highly computer-intensive, cutting-edge statistical research methods to find out how the HIV virus mutates to escape the human body’s immune system.
Specifically, HLA class 1’ is a controlling part of the human immune response. The ability of HIV to escape recognition by HLA class 1 leaves the body incapable of finding and fighting the virus.
Detailed study, published in the July issue of PLoS Pathogens, is the largest population-based investigation of how natural variations in HLA class 1 can influence HIV genetic sequence, as well as the first characterization of changes in multiple HIV genes in response to HLA-associated evolutionary pressure.
Scientist’s have successfully mapped sites within particular HIV genes where variations can improve the virus’s ability to escape immune recognition, showing this is predictable based upon the HIV patient’s individual HLA class 1 profile.
"This is a novel and advanced description of how the human immune system attacks the virus, and how it responds" says Richard Harrigan, PhD, director of the Center’s Research Laboratories and study co-author. "While we always knew the body attacks the virus and the virus changes to dodge pressure, we’re now more exact in knowing how this happens in people."
While the study is valuable in helping the scientific community understands how immune pressure impacts HIV, these findings hold tremendous promise in terms of global HIV efforts, says Sabrina Brume, PhD, the study’s lead author. "Achieving a more in-depth understanding of the ways in which HIV mutates to avoid the human immune system will help with the design of an HIV vaccine," says Brume, who is now with the Partners AIDS Research Center at MGH.
Data were collected from the British Columbia HOMER cohort, a large group of chronically HIV-infected, treatment-na ve individuals for whom HLA class-1 typing and HIV RNA genotyping were performed.
Microsoft Research provided personnel and advanced software tools to perform highly sophisticated statistical analysis. Algorithms developed by David Heckerman, lead researcher of the Machine Learning and Applied Statistics Group at Microsoft Research and study co-author, and his team allowed for more in-depth analysis of the data sets. "We created the software tools to help researchers exploit the power of computing to more quickly and accurately identify the crucial elements of an effective HIV vaccine," said Heckerman.
The original idea for the development of these statistical methods came from Bette Korber, PhD, at Los Alamos National Laboratory. Korber and co-researchers Tanmoy Bhattacharya, PhD, and Marcus Daniels worked with Heckerman in further developing the cutting-edge statistical approach.
Study results demonstrate that population-based approaches could complement smaller functional studies by providing a whole-gene or whole-virus picture of immune escape. Previous B.C. Centre research published in The Journal of Infectious Diseases investigated the role of HLA class 1 variation on response to anti-HIV therapy. "Moving forward, we’ll be expanding our genetic research to other HIV genes. We’ll also be investigating the role of drug therapy," says Harrigan.Information about HIV Virus AIDS symptoms
Information on HIV Virus and AIDS symptoms



Last updated: 01-Oct-2008

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