Authored By: B. V Waghmare

Friday, September 12, 2008


HOW WE CAN MAKE USE OF PART VACCINE AND CHEMOTHERAPY TOGATHER AS TARGETED DRUG DELIVERY TO INFECTED CELLS AND TO VIRUS.I want to share some knowledge on few research going on in field of vaccine development around the world , lets hope it will help some day to some on for doing and taking some great idea out of it and we get a vaccine or a drug for treating HIV AIDS, my intention of writing this blog is to share the knowledge base to every one . I am also inviting scientists in this field to write me their ideas so that we can share them around the world over this platform.
We know that we can produce a potent cancer vaccine which could be manufactured from a patient's own cancer cells and used to treat their tumour.
The technique involves the use of ultra-violet light to trigger the vaccine in a process known as photo-dynamic therapy (PDT). Tests on mice have shown that the technique produced a personalised vaccine with the same power as one grown in the laboratory, but in much less time.
The research was carried out by scientists at the British Columbia Cancer Agency, Vancouver, who were seeking new applications of PDT.
The technique uses ultraviolet light to trigger drugs when they reach their target, which means larger doses can be given without fear of toxic reactions in other parts of the body.
PDT has also been shown to stimulate an immune response against a tumour.
The new study involved taking samples of cancer tissue from mice with tumours and priming them with ultra-violet light. The cells were then grown overnight in the laboratory before being re-injected into the mice the following day.
The researchers found that priming the cells with ultra-violet light produced an increased immune response in the mouse when they were re-injected. Shining ultra-violet light on the cancer cells in effect created a potent cancer vaccine, though the mechanism behind this process is not understood.
The benefit of the technique is that it creates a personalised vaccine that can be injected straight back into the mouse with a minimum of delay, cutting out the time-consuming process of cultivating cells. The results of the study were published yesterday in the
British Journal of Cancer.
Dr Mladen Korbelik, senior author of the paper, said: "The prospect of using samples from a patient's own tumour to treat them is really exciting. This technique could mean that treatment is delivered more quickly and, most importantly, is tailored to the individual's cancer.
"Although our results showed this method produces powerful cancer vaccines, we're confident that this technique can be advanced further to be even more potent and effective."
Dr Lesley Walker, director of cancer information at Cancer Research UK, said: "This is an interesting application of PDT. Using targeted treatments with better delivery and manipulating the body's own immune system to fight the disease means patients would experience fewer side effects."
Information on HIV Virus and AIDS symptoms
This same technique can be developed for HIV Virus to specifically deliver a very potent drug to the virus and also the vaccine protein will help in developing immunity against the virus .we can tag a very potant antivirus drug with the part vaccine , personalised vaccine and tagged with antiviral drugs by formulating both in to a liposome drug delivery system. Here we can make use of photo-dynamic therapy .

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