Authored By: B. V Waghmare

Sunday, May 29, 2011

Dr. A H Bandivdekar finds the inhibitor for sexual transmission of HIV virus.

Dr. A H Bandivdekar finds the inhibitor for sexual transmission of HIV virus.
Dr. A H Bandivdekar Indian scientist found the exact way by which HIV virus gains entry in to human blood in sexual transmission of HIV virus, which is one of the biggest reason for HIV virus infections and AIDS.
We have few great out comes about process HIV virus infection. Amongst them Dr. A H Bandivdekar’s findings about mannose receptor involvement in sexually transmission of HIV virus will be of great value as it is going to save life’s of millions of peoples.

• Some individuals are tested HIV positive for years and do not develop AIDS.

1. There are certain individuals who are tested positive and do not develop symptoms of AIDS or AIDS this is because there is diffrerance in their genetic constitution , which do not allow HIV virus to grow in them so that they do not develop AIDS. Dr. Bruce Walker etal.

2. Just after HIV infection a person do not develop AIDS immediately . In latancy period there is a resistance for replication of HIV virus in lymphocytes in these infected individuals. There are certain CD 8 cells in HIV positive individuals which resist replication of HIV virus by not supporting synthesis of reverse transcriptase enzyme. Identifying these cells and using fractions of these cells could increase the latancy period in HIV positive individuals. Kannagi M etal.

• Work of Dr. A H Bandivdekar :- Finding mannose receptor responsible for transmission of HIV virus through vaginal lining in to blood.

CD4 independent binding of HIV gp120 to mannose receptor on human spermatozoa
Dr. A H Bandivdekar from India , Department of Biochemistry, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Parel, Mumbai, observed that there are certain couples where even after tested HIV positive the HIV virus is not transmitted to the partner ,
Systematic study and thinking by Dr. A H Bandivdekar led him to finding the key difference in the peoples who transmit the disease and who do not.
So far it was known to world that CD4 receptors were responsible for attachment and carrying HIV virus in to blood for further reproduction by replication.
Careful investigation by Dr. A H Bandivdekar proved that there is absence of CD4 receptors in viginal linings , and led to establish the possibility of different receptor responsible for transmission was studied and it was proved that there are different receptors than CD4 now known as mannose receptor are responsible for transmission of HIV trough vaginal lining , and in females which did not got HIV infection even after male partner being HIV positive it was found that these females lacked mannose receptors.
To establish this HIV gp120 protein which is an important part of HIV virus HIV gp120 protein has great role in the process of HIV virus infection was studied for its (HIV gp120 protein) binding to mannose receptors in human spermatozoa by Dr. A H Bandivdekar .
Dr. A H Bandivdekar has now found a molecule which can prevent transmission of HIV virus through these receptor, it will provide life saving remedy for peoples who are at high risk of getting HIV virus infection through sexual transmission.
Dr. A H Bandivdekar’s findings are really appreciable and encouraging the research on HIV and AIDS.

Referances
http://www.ncbi.nlm.nih.gov/pubmed/18614929

http://news.harvard.edu/gazette/story/2010/05/new-insights-into-the-mystery-of-natural-hiv-immunity/

http://gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102196055.html


B V Waghmare (2011). Dr. A H Bandivdekar finds the inhibitor for sexual transmission of HIV virus.
http://bvwaghmare.blogspot.com/ : bvwaghmare



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Last updated: 29-May-2011



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