Authored By: B. V Waghmare

Wednesday, January 7, 2009

INFORMATION ON AIDS HIV VIRUS|HIV AIDS Prevention Research and Development on AIDS vaccine and anti AIDS drugs| latest treatment for AIDS HIV POSITIVE

ANTI AIDS, HIV INFECTION TREATMENT,
WHAT WILL BE A POSSIBLE BREAKTHROUGH IN RESEARCH ON ANTI AIDS, HIV DRUGS
I AM GIVING HERE ALL POSSIBILITIES & BREAKTHROUGHS IN RESEARCH ON ANTI AIDS DRUGS.
IF YOU READ THIS WEBSITE THOROUGHLY YOU WILL GET ALL INFORMATION HIV VIRUS AND INFORMATION ON AIDS HOW HIV VIRUS INFECTS HUMAN
AND HOW TO PREVENT YOURSELF FROM HIV VIRUS.
YOU WILL FIND A VERY IMPORTANT AND UNIQUE INFORMATION ON HIV AIDS ONLY OVER THIS WEBSITE AS THIS WEBSITE IS WRITTEN BY A SCIENTIST WORKING ON VACCINE FOR HIV VIRUS AND ANTI AIDS DRUGS.
HE IS ASSOCIATED WITH ONE OF LEADING RESEARCH INSTITUTE IN USA.
WHAT ARE THE CURRENT MEDICINES USED FOR TREATMENT AND WHAT WILL BE THE POSSIBLE DRUGS FOR FIGHTING THIS DEADLY DISEASE
What is HIV?
HIV stands for Human Immunodeficiency Virus. HIV is the virus that causes AIDS. While many viruses can be controlled by our bodies immune system, HIV virus targets and infects the same immune system cells that are supposed to protect us from illnesses. These are a type of white blood cell called T-Lymphocytes. HIV takes over T-Lymphocytes cells and turns them into virus factories which intern produces thousands of HIV viral copies as HIV virus grows in number, it damages or kills T-Lymphocytes cells, weakening the immune system.
AIDS stands for Acquired Immune Deficiency Syndrome. AIDS is the most advanced stage of HIV infection. HIV causes AIDS by attacking the immune system’s soldiers – the T-Lymphocytes cells . When the immune system loses too many T-Lymphocytes , you are not able to fight any sort of infection and a simpler infection can develop serious, often to a deadly, infections. These are called opportunistic infections (OIs) because they take advantage of the body's weakened defenses. When someone dies of AIDS, it is usually opportunistic infections or other long-term effects of HIV infection that cause death.
AIDS refers to the body’s immune-compromised state that can no longer stop OIs from developing and becoming so deadly.
You don't have AIDS as soon as you are infected with HIV. You can remain HIV+ve for many years with no signs of disease, or only mild-to-moderate symptoms. But without treatment, HIV will eventually wear down the immune system in most people to the point that they develop more serious OIs. The Centers for Disease Control and Prevention (CDC) USA defines someone as having AIDS if he or she is HIV+ and meets one or both of these conditions:
Has had at least one of 21 AIDS-defining opportunistic infections Has had a CD4 cell count (T-cell count) of 200 cells or less (a normal CD4 count varies by laboratory, but usually is in the 600 to 1,500 range)
Most people can not tell that they have been exposed or infected. It can take up to 12 weeks for an HIV test to come back positive. However most people respond much faster. Within two to four weeks of exposure to HIV, you might have flu-like symptoms such as fever, swollen glands, muscle aches, or rash. The only way to know for sure if you are infected is take an HIV test. If you are infected, your immune system will make antibodies to fight the virus. The HIV test looks for these antibodies. If you have them in your blood, it means that you have HIV infection.
Do I Need to Get Tested for HIV?
The CDC estimates that more than 25% of HIV+ people are unaware of their HIV status. Many of these people look and feel healthy and do not think they are at risk. But the truth is that anyone of any age, gender, race, sexual orientation, or social or economic class can become infected. It is your actions (or the actions taken against you), that put you at risk. You should be tested if: You have had vaginal, anal, or oral sex without a condom You have shared needles or syringes to inject drugs (including steroids or hormones) You are uncertain of your partner’s status or your partner is HIV+ve. You are pregnant or are considering becoming pregnant You have ever been diagnosed with a sexually transmitted disease You have hepatitis C Why Should I Get Tested?If you test HIV+ there are effective medications to help you stay well. But you cannot get the health care and treatment you need if you do not know your HIV status. Being unaware of your status also makes it more likely to unknowingly pass HIV to others. If you test HIV- you can take steps to stay that way. You can also spare yourself unnecessary worrying. What Tests are Available?The most common test for HIV is the antibody test (called ELISA). It can be done on blood, saliva, or urine. According to the CDC, it is more than 99% accurate. Results are generally available within two weeks. (There is a rapid ELISA test that gives results in less than half an hour.) A positive result means your body has developed antibodies for HIV, so you are infected with the virus. To be completely certain, positive results are confirmed with a more sensitive test called the Western blot. A negative result means your body has not developed antibodies and are probably not infected. To get truly accurate results, it's necessary to wait three to six months after your last possible exposure to the virus before being tested. That is because the immune system can take anywhere from three to twelve weeks to make antibodies. In this "window period," someone may get an unclear result or a false negative.

A BRIFE INFORMATION ON HIV VIRUS :
WHAT ARE THE CHALLENGES TO FIGHT AGAINST THIS VIRUS
HIV virus is a T -lymphocytic RNA Virus which is classified as Retrovirus , it uses RNA to as its source for genetic information, It do not contain its own DNA,where as it uses RNA for first forming a (DNA copy ) for its multiplication with help of reverse transcriptase enzyme, after it gets entry in hosts cell this is called reverse transcription (RNA TO DNA AND TO PROTEIN SYNTHESIS). The process of normal cell DNA multiplication is called trancription(DNA TO RNA AND TO PROTEIN SYNTHESIS). as protein synthesis and multiplication is a process only DNA can bring about.virus intercalates and instigates its (DNA copy ) in human DNA and thus , when ever our body , cell under goes multiplication or , it brings about protein synthesis for our body for normal metabolism , our cell by default also synthesizes Virus RNA ,and Virus proteins ,and these Viral RNA and proteins assemble together to form a new virus (Process of virus multiplication). The enzyme which help virus to Integrate its (DNA copy ) in Human DNA is Intercalase , for this (DNA copy ) to get proper place in Human DNA a enzyme , Ligaase , which cuts Human DNA at correct required Point . This point Varies in Person to person ,it will be different in different individuals and hence a mutation occurs in Virus DNA ,and newly Virus thus formed is different from original, which is mutation. These are the enzyme which has made this virus very deadly, as it moves from one human to other , its genetic code for protein amino acid sequence changes , and it makes difficult to establish a identity from one host to other ,consider it as a mutation from one virus to other. that is the reason why we are not able to produce vaccine for this. as there are challenges there are solutions,
WHAT ARE THE SOLUTIONS .....the author of this blog is a Pharmacists and these are his views which are fundamentals for today's research and dvelopment going on HIV AIDS Vaccine anti AIDS drugs ,and Personalised HIV Vaccine ......
Virus Has a unique way of infecting host cell, that is through CD4 RECEPTOR over T -LYMPHOCITC CELLS (a main part of human body to provide immunity against any sort of infection) hence method of attachment to CD4 receptor is same , hence we can possibly identify the sequence of amino acid in the protein coat over counter part on HIV virus which attaches to CD4 RECEPTOR, This protein sequence can enable us to develop a part of protein of virus and we can use this as a VACCINE , .......This is what is currently happening for part vaccines ...dendritic cells ..antigen presenting to novice body..
HOW IS THE CHEMOTHERAPY DESIGNED ?
HIV VIRUS contains RNA ,and our body cells contain DNA, and only key difference in both, is a Nucleotide Thiamine Trineuclio Phosphate , if we are able to stop , usage of this nucleotide by virus , eventually we can stop virus reproduction, and growth of virus as RNA for next virus is not synthesized there by stooping growing and will stop killing our body defence mechanism.
This is what is done by available medicines like Azidothymidine, Zudovudine, same way virus multiplication can be hampered by using Uracil anti metabolite , where you can incorporate -N=NH moiety like in zudovudine and it can survive as DNA elongation step inhibitor. it may be equally harmful to Patients body beyond some extent. Hence combination Therapy ,which will help take care of infective process of virus at all stages of infection has to be blended together, Drugs should be combined to, 1.Genetically engineered CD4(Partial Vaccines):- Here we can Design CD4 receptor in vitro (genetic engineering) and these engineered receptor will get targeted by virus and there by make it loss its RNA in serum before entry in host cell.
2. Drugs which inhibit attachment :- eg:- amantadine
3. Drugs which will hamper integration of PRO VIRUS TO HUMAN DNA . URACIL ANTI METABOLITE,
4. Reverse transcriptasae inhibitors
virus synthesizes its DNA from RNA
(THIS IS CALLED REVERSE TRANSCRIPTION)
in host cell after geting in host cell eg:- AZIDOTHYMYDINE.
5.Intigraese inhibitor:-these drugs are under development and are suppose to inhibit Pro virus DNA to integrate in o Human DNA. 6.Immunoglobulines :-They Surround HIV virus and its components , and neutralize its activity.
6:- Poly -Poly units:- eg :- poly -ala.(POLY ALANINE)
Inhibits reverse transcription,And intigrasae.by forming a back bone Hydrogen bonding with cDNA strands in process of replication , and thus Reverse-transcription,and Transcription is inhibited.
This group of molecules are extensively required to be studied for the anti retro viral activity
Combination of all step inhibitors will give good result.
There are other many drugs which are required to be tested To know in detail about aids HIV drugs used on HIV aids read this blog in detail.

I have written all information about HIV VIRUS & AIDS and i have written about HIV AIDS treatment. and about following topics.
Why it is difficult to develop a vaccine for HIV AIDS
What are the current mode of treatment for HIV AIDS
What should be done in of accidental contact with HIV infected object
what is current research on AIDS
What are the current drugs which are effectively used for treating HIV positive individuals and AIDS.
What should be the approach for research and development of anti AIDS drugs and vaccine.
Is there possibilities for complete life saving treatments by genetic engineering and gene therapy
What is latest treatment for aids HIV available,information on HIV virus and Information on AIDS
What precautions are required to be taken by every one so that he is not infected by HIV virus
You will find answers for your all questions about HIV virus and AIDS, information on HIV virus and Information on AIDS
Information about AIDS medicines
AIDS symptoms
SYMPTOMS OF HIV
HIV symptoms
If you want to join me in fight against HIV virus and AIDS to save this world you just have to send me a email to webmster of our website
and send this blog to all of your friends and dear ones by email so that you help them to protect them against this disease.
Information about HIV Virus AIDS symptoms
===================================================
Source:

Question and Answers about HIV Testing -->http://www.cdc.gov/hiv/topics/testing/resources/qa/index.htm

Signes and symptoms of AIDS and HIV infection--> http://www.aids.gov/hiv-aids-basics/hiv-aids-101/overview/signs-and-symptoms/

Basic Information about HIV and AIDS ==>http://www.cdc.gov/hiv/topics/basic/index.htm

===================================================

=========================================
Advertisements
=========================================
Pharmaceutical Manufacturing


Pharmaceutical Industry


Pharmaceutical Companies
========================================

Last updated: 07-Jan-2009



2 comments:

Puneet Jain said...

Good work done! Keep it up and make it precise not too lengthy.. Thats all I say as your wellwisher.


Your Truly
Puneet

Anonymous said...

hi